Can RYZE Mushroom Coffee cause side effects? It can be a concern if you are sensitive to caffeine, have digestive or kidney concerns, take certain medicines, or react to mushrooms. RYZE says its coffee contains about 48 mg of caffeine per cup and a blend of six mushrooms; the most useful next step is to match those ingredients to your own medicines, health history, and caffeine tolerance.
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What is in RYZE Mushroom Coffee?
RYZE lists Arabica coffee, MCT oil, and its SUPER6 mushroom blend: cordyceps, lion’s mane, reishi, shiitake, turkey tail, and king trumpet. The brand markets the drink for everyday energy, focus, mood, gut health, and immune support.
The ingredient page names the six species but does not show an individual amount for each mushroom. That matters if you want to compare one species with a human study, because a study dose for one isolated extract is not the same thing as an amount inside a multi-mushroom coffee blend.
Evidence grade: limited and indirect for mushroom coffee. There is human research on particular mushroom preparations, but it does not establish what a finished mixed coffee will do for you. NCCIH also notes that store-bought supplements can differ in important ways from products used in studies.
Could the caffeine cause jitters, sleep trouble, or higher blood pressure?
RYZE says one cup has about 48 mg of caffeine. Caffeine sensitivity differs widely. The FDA says too much caffeine can cause jitters, anxiety, upset stomach, nausea, insomnia, a faster heart rate, palpitations, and higher blood pressure. For most adults, the FDA cites 400 mg a day as an amount not generally associated with negative effects, but medicines, pregnancy, health conditions, and personal sensitivity can change that number for you.
So, does RYZE raise blood pressure? A cup contains caffeine, and caffeine can raise blood pressure in some people, especially when the total daily amount is more than their body tolerates. The practical question is not only this cup: count coffee, tea, energy drinks, chocolate, and other caffeine sources in the same day.
If coffee already gives you palpitations, anxiety, reflux, or poor sleep, that pattern is worth discussing with a clinician before adding a mushroom coffee. The FDA specifically advises people who are pregnant, trying to become pregnant, breastfeeding, or concerned about a condition or medicine to ask a health professional about caffeine limits.
What side effects can the mushroom ingredients bring?
Mushroom coffee combines coffee with mushroom powders or extracts, so digestive comfort and kidney history are common questions. Cleveland Clinic notes that mushroom products may cause digestive issues for some people and highlights chaga’s oxalates as a concern for people with kidney issues or kidney stones.
| Ingredient RYZE lists | What the safety sources say | What it means for you |
|---|---|---|
| Lion’s mane Hericium erinaceus |
Memorial Sloan Kettering Cancer Center lists abdominal discomfort, nausea, and skin rash as possible side effects. | Take note if you have had a mushroom allergy, rash, nausea, or stomach discomfort with supplements before. |
| Reishi Ganoderma lucidum |
MSKCC lists nausea, insomnia, and liver injury among possible side effects. It says reishi may increase bleeding risk with warfarin and may not be suitable with immunosuppressants. | This is the main reason to ask first if you use a blood thinner, take immune-suppressing medicine, or have a liver concern. |
| Cordyceps | MSKCC reports no major side effects but flags possible interaction concerns with blood-sugar medicines and blood thinners. | Ask the clinician who manages those medicines before using a cordyceps-containing blend. |
| Turkey tail Trametes versicolor |
MSKCC lists dark stool and darkened fingernails as possible effects and says safety in pregnancy or breastfeeding is not known. | Pregnancy and breastfeeding are good reasons to get individual advice before using a turkey-tail blend. |
| Chaga | Cleveland Clinic notes that chaga is high in oxalates and may affect or increase kidney stones. | If you have kidney stones, kidney disease, or an oxalate-related concern, bring the label to your clinician first. |
These are ingredient-level safety points, not proof that RYZE itself will cause a particular reaction. If you want a broader overview of allergy questions by species, see mushroom allergy safety.
What do human studies actually say about the mushrooms?
The best-known research is often about a single species, a defined preparation, and a specific group of people. For lion’s mane, a small 2025 acute trial used 3 g of a 10:1 fruiting-body extract in 18 adults. It found no significant overall cognition or mood effect, although one task showed an isolated signal. That is useful context for lion’s mane research, but it is not a dose match for an undisclosed amount in a mixed coffee.
Human work on cordyceps has included exercise endpoints, but findings vary by species, preparation, dose, participants, and outcome. Reishi research is mixed and indication-specific. Turkey-tail research includes specialized PSK and PSP extracts in medical settings, which are not interchangeable with a general mushroom-coffee blend. The National Cancer Institute describes turkey-tail research in its medicinal mushroom overview, including the distinction between specific preparations and study settings.
Shiitake has been studied as a whole food in a dietary intervention, not as a small amount inside a coffee blend. Chaga has limited human efficacy research; its safety discussion is more helpful here than broad benefit claims. A species-by-species page on turkey tail research and safety explains why extract type and study setting matter.
Is RYZE coffee healthy for your heart, cholesterol, or liver?
It is more useful to separate the coffee from the claims around it. Coffee contains caffeine, which may be comfortable for one person and troublesome for another. Mushroom ingredients have research histories, but ingredient research does not show that a finished mushroom coffee lowers cholesterol, supports a particular organ, or changes heart risk.
Reishi has been researched in several settings, including cholesterol-related questions, but MSKCC says randomized trials did not support its use for cardiovascular risk factors associated with type 2 diabetes. The rare liver reports associated with reishi are a reason to take liver symptoms seriously and ask a clinician before using a blend that includes it if you have a liver condition or take medicines processed by the liver.
For cholesterol questions, oyster mushrooms are a different species and food context from the RYZE blend. Our guide to oyster mushrooms and cholesterol safety explains that distinction.
What about stomach upset and negative reviews?
People commonly want to know whether a new coffee will feel easy on their stomach, taste acceptable, fit their sleep routine, or be worth the price. Digestive upset can come from coffee, caffeine, added ingredients, or an individual response to mushroom products. Cleveland Clinic advises people with digestive or kidney concerns to speak with a healthcare professional before trying mushroom coffee.
Customer comments are personal experiences, not a reliable way to predict what will happen to you. Use them for practical questions such as preparation, taste, shipping, and subscription terms; use the ingredient list, caffeine amount, and medicine-interaction questions for a safety decision.
RYZE price, preparation, and refund terms
RYZE says to start with 1–2 tablespoons in 4–6 ounces of hot water or milk, then add creamer or sweetener if you like. Prices shown on October 6, 2026 were part of a limited-time sale, so check checkout for today’s price.
| Detail | What RYZE says |
|---|---|
| Bag size | 30 servings |
| Sale price shown | $27, or $0.90 per serving, during the countdown sale |
| Subscription refill shown | $36 shipped in 30 days |
| Caffeine | About 48 mg per cup |
| Return timing | Contact RYZE within 30 days of delivery to request a return label |
| Opened product | The brand’s Love-It Guarantee says a first subscription order may qualify for a refund on one opened bag; its standard return policy otherwise says unopened, intact-seal items are required unless the item is damaged or defective. |
RYZE says shipments can be adjusted or canceled. If you order, save your confirmation and use the return instructions on the brand’s policy page if you need help.
How does RYZE compare with a ground mushroom coffee?
Compare coffee options by form, disclosed ingredients and amounts, caffeine disclosure, sugar, servings, price per serving, and return window—not by a promised outcome. RYZE is an instant drink mix with six named mushrooms and about 48 mg caffeine per cup; its individual mushroom amounts are not shown on the ingredient page.
| Check before buying | RYZE Mushroom Coffee | Pilly Vitality Mushroom Coffee |
|---|---|---|
| Form | Instant drink mix | Ground coffee for drip, pour-over, or French press |
| Listed mushrooms | Cordyceps, lion’s mane, reishi, shiitake, turkey tail, and king trumpet | Lion’s mane and chaga |
| Ingredient amounts | Individual mushroom amounts are not shown on the ingredient page | The product page lists lion’s mane and chaga in the formula, but individual mushroom amounts are not shown on the ingredient page. |
| Caffeine | About 48 mg per cup, according to RYZE | Contains caffeine; the amount is not disclosed on its page |
| Sugar | Ask the brand or check the current package for the full nutrition panel | 0 g sugar listed |
| Servings and price | 30 servings; $27 sale price shown on October 6, 2026 | 34 servings; $47.99 regular price shown |
| Return window | Contact within 30 days of delivery; terms differ for opened subscription and standard returns | 30-day satisfaction-review window |
If ground coffee and a two-mushroom formula fit your routine, Vitality Mushroom Coffee is one label to compare. It is not the same form or formula as RYZE.
Who should ask a clinician before trying RYZE?
- Anyone taking blood thinners, antiplatelet medicines, insulin, other blood-sugar medicines, blood-pressure medicine, or immunosuppressants.
- Anyone scheduled for surgery. See mushrooms before surgery for the questions to raise.
- Anyone pregnant, breastfeeding, managing a liver or kidney concern, or with a history of kidney stones.
- Anyone with a mushroom or mold allergy, or who has had rash, nausea, abdominal discomfort, palpitations, or sleep trouble with coffee or supplements.
- Anyone deciding whether a mushroom product fits a child’s or teenager’s routine; see mushroom supplements for children.
Bring the current RYZE ingredient page and your medication list. That gives the clinician the details needed for a useful answer.
By MushroomHealthBenefits.com Research & Editorial Team
This article is for general information purposes only and does not constitute medical advice. Consult your doctor or qualified healthcare provider before making changes to your health routine.